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Cover picture: Molecular dynamics model of the SecY channel in the membrane. Views highlighting the central pore ring (yellow surface) are shown in the middle and right panels. Simulations reveal that the ring is mainly responsible for closing SecY. Plugs in native and two mutated channels are shown in green, blue, and red, respectively; these stabilize ring closure, but do not seal the channel (see article by Gumbart and Schulten, 709–719).
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