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Cover picture: Retinal photoreceptor metabolism increases in the dark, leading to increased deposition of CO2 and water into the subretinal space (SRS). The retinal pigment epithelium can mitigate this potentially catastrophic metabolic load by increasing CO2/HCO3, Na, and H2O absorption from the SRS into the choroidal blood supply via Na-linked HCO3 transporters, thus preventing SRS acidosis and retinal detachment (see article by Adijanto et al., 603–622).
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