TY - JOUR
T1 - ON THE INTENSITY-TIME RELATIONS FOR STIMULATION BY ELECTRIC CURRENTS. I
JF - The Journal of General Physiology
JO - J Gen Physiol
SP - 709
LP - 729
DO - 10.1085/jgp.15.6.709
VL - 15
IS - 6
AU - Blair, H. A.
Y1 - 1932/07/20
UR - http://jgp.rupress.org/content/15/6/709.abstract
N2 - Formulae are derived for the time-intensity relations for stimulation by direct currents using the following hypotheses: first, the current produces an excitatory effect whose rate of growth is proportional to the voltage; and second, the tissue reacts toward the normal state at a rate proportional to the amount of excitation. If p represents the local excitatory process numerically, the hypotheses are represented by the differential equation See PDF for Structure. where K and k are constants and V the applied voltage. For the stimulus to be adequate it is assumed that p must be built up to a certain liminal value. It appears as a deduction from the data that this liminal value is a function of the voltage of the form h ± αV where h and α are constants. α is zero or negligible for certain electrodes. αV is a measure of electrotonus or a similar phenomenon. Experimental data are discussed and are shown to agree satisfactorily with the derived formulae for stimulation both at the anode and cathode.
ER -