Table 4.

Model parameters

Channel domainTransitionForward rateReverse rate
DI L689IA↔I11.11E-044.45E-04
I1↔I23.97E-052.24E-05
I2↔I33.33E-049.48E-01
DII L689IA↔I14.91E-053.56E-04
I1↔I24.79E-053.03E-05
I2↔I36.19E-094.91E-02
DIII L689IA↔I12.18E-044.63E-04
I1↔I23.82E-052.38E-05
I2↔I32.97E-043.55E-03
DIV L689IA↔I12.13E-043.99E-04
I1↔I21.83E-052.27E-05
I2↔I34.88E-049.91E-01
  • The discrete-state Markov models used in Fig. 8 in our companion paper (Silva and Goldstein, 2013) are parameterized for the forward and reverse rate transitions between states A and I1, states I1 and I2, and states I2 and I3 for the L689I mutation in each of the voltage-sensor domains.