Table 3.

Allosteric model parameters for I696X in the absence of capsaicin

ChannelJ0zgLDΔGo
kcal/mol
TRPV10.0210.600.000534,5001.7
I696V0.0180.600.000478,5001.5
I696L0.0190.600.000506,0001.6
I696M0.0180.620.000492,0002.1
I696H0.0210.600.000494,0001.8
  • Normalized g-V curves (Fig. 8 A) were fitted to the Eq. 1, and free energies were obtained using Eq. 2.