Table 2.

Canonical CaM-binding motifs in helix B of KCNQ channels

MotifKCNQ1KCNQ2KCNQ3KCNQ4KCNQ5
ResiduesSequenceResiduesSequenceResiduesSequenceResiduesSequenceResiduesSequence
1–10514–523IKVIRRMQYF536–545LKVSIRAVCV515–524LKAAIRAVRI530–539VKTVIRSIRI518–527LKTVIRAIRI
540–549IRAVCVMRFL525–534LQFRLYKKKF533–542VIRSIRILKF521–530VIRAIRIMKF
534–543IRSIRILKFL
540–549LKFLVAKRKF
1–5–10536–545LKVSIRAVCV515–524LKAAIRAVRI530–539VKTVIRSIRI518–527LKTVIRAIRI
525–534LQFRLYKKKF533–542VIRSIRILKF521–530VIRAIRIMKF
540–549LKFLVAKRKF
1–12506–517LREHHRATIKVI532–543LTPGLKVSIRAV526–537IMPAVKTVIRSI514–525LTPPLKTVIRAI
538–549VSIRAVCVMRFL533–544VIRSIRILKFLV521–532VIRAIRIMKFHV
1–14516–529VIRRMQYFVAKKKF532–545LTPGLKVSIRAVCV512–525IPTLKAAIRAVRIL526–539IMPAVKTVIRSIRI514–527LTPPLKTVIRAIRI
536–549LKVSIRAVCVMRFL530–543VKTVIRSIRILKFL
1–8–14516–529VIRRMQYFVAKKKF536–549LKVSIRAVCVMRFL512–525IPTLKAAIRAVRIL526–539IMPAVKTVIRSIRI514–527LTPPLKTVIRAIRI
530–543VKTVIRSIRILKFL
1–5–8–14536–549LKVSIRAVCVMRFL526–539IMPAVKTVIRSIRI514–527LTPPLKTVIRAIRI
530–543VKTVIRSIRILKFL
1–16514–529IKVIRRMQYFVAKKK540–555IRAVCVMRFLVSKRK512–527IPTLKAAIRAVRILQF534–549IRSIRILKFLVAKRKF522–537IRAIRIMKFHVAKRKF
519–534IRAVRILQFRLYKKKF
  • CaM motifs are described in Table 1.