Table 1.

Canonical CaM-binding motifs

MotifSequence
Ca2+ dependent
1–10[FILVW]xxxxxxxx[FILVW]
1–5–10[FILVW]xxx[FAILVW]xxxx[FILVW]
Basic 1–5–10[RK][RK][RK][FAILVW]xxx[FILV]xxxx[FILVW]
1–12[FILVW]xxxxxxxxxx[FILVW]
1–14[FILVW]xxxxxxxxxxxx[FILVW]
1–8–14[FILVW]xxxxxx[FAILVW]xxxxx[FILVW]
1–5–8–14[FILVW]xxx[FAILVW]xx[FAILVW]xxxxx[FILVW]
Basic 1–8–14[RK][RK][RK][FILVW]xxxxxx[FAILVW]xxxxx[FILVW]
1–16[FILVW]xxxxxxxxxxxxxx[FILVW]
Ca2+ independent
IQ[FILV]Qxxx[RK]Gxxx[RK]xx[FILVWY]
IQ-likea[FILV]Qxxx[RK]xxxxxxxx
IQ-2A[IVL]QxxxRxxxx[VL][KR]xW
IQ-2B[IL]QxxCxxxxKxRxW
IQ unconventional[IVL]QxxxRxxxx[RK]xx[FILVWY]
  • Numbers for the Ca2+-dependent motifs indicate the positions that require a hydrophobic residue. Residues in the brackets can substitute for each other; x indicates any amino acid residue.

  • a Some IQ-like motifs require Ca2+ for CaM binding.