Table II

Permeability of Wild-Type Channels to Intracellular Anions

Intracellular anionErevPX/PCln
mV
Chloride01.008
Iodide+15.5 ± 1.41.82 ± 0.106
Bromide +5.8 ± 3.51.26 ± 0.174
Fluoride−46.7 ± 11.70.17 ± 0.075
Nitrate+11.3 ± 1.41.61 ± 0.096
Formate−35.4 ± 0.00.25 ± 0.004
Bicarbonate−34.5 ± 1.50.25 ± 0.013
Acetate−41.5 ± 0.40.19 ± 0.013
PropanoateNo reversal<0.062
PyruvateNo reversal<0.064
Methane sulfonateNo reversal<0.063
Ethane sulfateNo reversal<0.065
GluconateNo reversal<0.066
  • Summary of mean reversal potentials and permeability ratios measured with different intracellular anions in wild-type channels. See Table I for details.