TABLE I

Characteristics of pBoc and Intestinal Ca2+ Oscillations and Ca2+ Waves in Control Worms (glo-1) and itr-1 Mutants

AllelepBoc periodpBoc CVCa2+ oscillation periodCa2+ oscillation CVCa2+ oscillation rise timeCa2+ oscillation fall time
s%s%ss
glo-155 ± 1 (6)4 ± 1 (6)49 ± 3 (6)16 ± 1 (6)8 ± 1 (5)23 ± 3 (5)
itr-1(sa73)111 ± 10a (6)9 ± 3 (6)271 ± 30a,b (6)24 ± 7 (6)17 ± 2a (6)30 ± 6 (6)
itr-1(sy290)49 ± 1 (6)4 ± 1 (6)50 ± 3 (6)10 ± 3 (6)6 ± 1 (6)17 ± 3 (6)
itr-1(sy327)53 ± 2 (9)8 ± 2 (9)42 ± 2 (7)11 ± 1 (7)5 ± 1 (7)20 ± 1 (7)
  • a P < 0.001 compared with glo-1 control animals.

  • b P < 0.002 compared with pBoc in itr-1(sa73) worms.

  • Values are means ± SEM (n = number of worms or intestines). Fluorescence images were acquired at 1–10-s intervals.