TABLE I

Relative Permeability for A713X Homomeric Channels

IsoformPLiPKPCsPNMDG
A713wt1.30 ± 0.04 (5)0.24 ± 0.02 (5)0.14 ± 0.01 (5)0.20 ± 0.02 (5)
A713G1.45 ± 0.07 (6)0.27 ± 0.07 (6)0.19 ± 0.08 (5)0.09 ± 0.03 (6)
A713C1.19 ± 0.02 (5)0.34 ± 0.07 (5)0.19 ± 0.03 (5)0.12 ± 0.02 (5)
A713Tb1.44 ± 0.04 (19)0.17 ± 0.02 (21)0.044 ± 0.003 (14)0.0140 ± 0.0009 (14)
A713D1.66 ± 0.04 (4)a0.26 ± 0.02 (5)0.12 ± 0.03 (5)0.06 ± 0.01 (5)a
A713V1.54 ± 0.08 (5)0.17 ± 0.02 (5)0.04 ± 0.01 (5)0.10 ± 0.04 (5)
  • Ionic permeability relative to that for Na+ (PX/PNa) was measured for indicated isoforms in two-electrode voltage clamp. Values are Px/PNa and are expressed as mean ± SEM (n). One-way ANOVA for Px/PNa: PLi, F(5,38) = 5.852, P = 0.0004; PK, F(5,40) = 2.966, P = 0.0.0227; PCs, F(5,33) = 3.738; P = 0.0086; PNMDG, F(5,39) = 5.688; P = 0.0.0049.

  • a P < 0.01; pairwise Dunnet's test with respect to wild type.

  • b Data for A713T are from Goodman et al. (2002).