Table I.

Biophysical properties of heteromeric Kv1 channels

ParametersAdjacent Kv1.1-1.1-1.2-1.2Reverse adjacent Kv1.2-1.2-1.1-1.1Diagonal Kv1.1-1.2-1.1-1.2Reverse diagonal Kv1.2-1.1-1.2-1.1
τact at 0 mV (ms)1.9 ± 0.1 (3)2.3 ± 0.6 (3)1.4 ± 0.1 (3)1.3 ± 0.1 (4)
τinact1 at 0 mV (ms)540 ± 2 (5)529 ± 50 (4)306 ± 34 (3)a341 ± 17 (4)a
τinact2 at 0 mV6,200 ± 500 (5)5,053 ± 596 (4)3,586 ± 485 (3)4,372 ± 404 (4)
V 1/2 (mV)−17 ± 1 (9)−18 ± 1 (14)−22 ± 1 (7)a−21 ± 1 (10)a
Slope (k)11 ± 1 (9)12 ± 1 (14)11 ± 1 (7)10 ± 1 (10)
  • Values (mean ± SEM) for activation and inactivation were derived by fitting to single- and double-exponential functions, respectively. V1/2 and slope k were calculated from Boltzmann equation fitting of the gk-V plots.

  • a Significant difference from adjacent constructs (P < 0.05; Mann-Whitney U test).