Equivalent amino acid numbers are shown for A. californica (Aplysia Slo1), mouse (mBK), and human BK (hBK). Table rows are color coded according to residue location: S6 (red), Mg2+-binding site (orange), RCK1 Ca2+-binding site (gray), and Ca2+ bowl (blue). Sequence alignment was performed using the Clustal Omega tool from EMBL-EBI and the following protein sequences: A. californica high conductance calcium-activated potassium channel (GenBank accession no. AAR27959.1), Mus musculus mbr5 mslo (GenBank accession no. AAA39746.1), and Homo sapiens calcium-activated potassium channel subunit α-1 isoform b (GenBank accession no. NP_002238.2).
a Conserved residue.
b Nonconserved residue.