Table 2. The summary of experimentally determined parameters for the two PaMscS channels in comparison to EC MscS
ChannelΔEΔAP0.5MscS/P0.5MscLConductanceSelectivity PCI/PKInactivationRecovery time
kTnm2nS%s
EC MscS∼20–28 (Akitake et al., 2005)∼12–14 (Akitake et al., 2005; Boer et al., 2011)0.58 ± 0.02 (n = 12)∼1–1.1 (Sukharev, 2002)∼1.5 (Sukharev, 2002)36 ± 5 (n = 15)1.5–3 (Akitake et al., 2005)
PaMscS-117.1 ± 0.5 (n = 16)11.0 ± 0.5 (n = 16)0.47 ± 0.01 (n = 4)0.96 ± 0.02 (n = 3)∼1.5 (n = 3)40 ± 8 (n = 10)30 ± 6 (n = 4)
PaMscS-215 ± 2 (n = 3)10 ± 1 (n = 3)0.51 ± 0.01 (n = 4)0.55 ± 0.02 (n = 3)∼4.4 (n = 3)64 ± 3 (n = 7)200 ± 70 (n = 3)

The degree of inactivation was measured at saturating pressure after a 10-s conditioning pressure step of amplitude around p0.5.