Table 1. Structures of mAChRs
ReceptorLigandLigand typeProtein Data Bank accession numberResolution (Å)Reference
M1R-T4LTiotropiumInverse agonist5CXV2.7Thal et al., 2016
M2R-T4LQNBInverse agonist3UON3.0Haga et al., 2012
M2R•Nb9.8IperoxoAgonist4MQS3.5Kruse et al., 2013
M2R•Nb9.8Iperoxo + LY2119620Agonist + PAM4MQT3.7Kruse et al., 2013
M3R-T4LTiotropiumInverse agonist4DAJ3.4Kruse et al., 2012
M3R-dsT4LTiotropiumInverse agonist4U143.6Thorsen et al., 2014
M3R-mT4LTiotropiumInverse agonist4U152.8Thorsen et al., 2014
M3R-mT4LNMSInverse agonist4U163.7Thorsen et al., 2014
M4R-mT4LTiotropiumInverse agonist5DSG2.6Thal et al., 2016