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Newest Articles

  • The discovery of the ability of rod photoreceptors to signal single photons
    The discovery of single-photon signaling

    A retrospective on the scientific importance and impact of Hecht, Shlaer, and Pirenne’s classic 1942 paper, “Energy, Quanta, and Vision.”

    Edward N. Pugh
    Milestone in Physiology | February 21, 2018
  • Improving the characterization of calcium channel gating pore currents with Stac3
    Calcium channel gating pore currents

    Chahine highlights new work that exploits the increased expression of human CaV1.1 at the plasma membrane after coexpression with Stac3.

    Mohamed Chahine
    Commentary | February 21, 2018
  • Stac proteins associate with the critical domain for excitation–contraction coupling in the II–III loop of Ca<sub>V</sub>1.1
    Stac proteins interact directly with CaV1.1

    In skeletal muscle, excitation–contraction coupling between CaV1.1 and RyR1 depends on the presence of a critical domain (residues 720–764/5) within the cytoplasmic II–III loop of CaV1.1. Polster et al. identify the adaptor protein Stac3 as a direct interaction partner of the critical domain.

    Alexander Polster ... Kurt G. Beam
    Research Article | February 21, 2018
  • Another way of seeing things
    Another way of seeing things

    JGP study explores a novel photoreception pathway in a marine mollusk.

    Caitlin Sedwick
    Research News | February 20, 2018
  • Protein phosphorylation maintains the normal function of cloned human Ca<sub>v</sub>2.3 channels
    Phosphorylation prevents Cav2.3 channel run-down

    Cav2.3 Ca2+ channels are subject to cytosolic regulation, which has been difficult to characterize in native cells. Neumaier et al. demonstrate the role of phosphorylation in the function of these channels and suggest a close relationship between voltage dependence and the phosphorylation state.

    Felix Neumaier ... Toni Schneider
    Communication | February 16, 2018
  • A kinetic account for amphetamine-induced monoamine release
    Cooperative binding of Na+ and substrate to SERT

    This study on serotonin transporters shows that amphetamine-induced monoamine release requires cooperative substrate and cosubstrate binding. A kinetic model is presented that can account qualitatively and quantitatively for the releasing action of amphetamines.

    Peter S. Hasenhuetl ... Walter Sandtner
    Research Article | February 09, 2018
  • Coarse-grained molecular dynamics simulations reveal lipid access pathways in P-glycoprotein
    Lipid access pathways in P-glycoprotein

    P-glycoprotein contributes to multidrug resistance by exporting a broad range of substrates across the cell membrane. Using molecular dynamics simulations, Barreto-Ojeda et al. identify key lipid-binding sites and reveal lipid access pathways toward the cavity of the transporter.

    Estefania Barreto-Ojeda ... D. Peter Tieleman
    Research Article | February 06, 2018
  • Stac3 enhances expression of human Ca<sub>V</sub>1.1 in <em>Xenopus</em> oocytes and reveals gating pore currents in HypoPP mutant channels
    Gating pore currents in HypoPP hCaV1.1

    Hypokalemic periodic paralysis (HypoPP) is thought to be caused by an aberrant inward current through the voltage sensors of mutant Na+ or Ca2+ channels. Wu et al. use Stac3 to enhance the membrane expression of two HypoPP CaV1.1 mutants in oocytes and find that both support gating pore currents.

    Fenfen Wu ... Stephen C. Cannon
    Research Article | January 31, 2018
  • Concatenated nicotinic acetylcholine receptors: A gift or a curse?
    Optimizing Cys-loop receptor concatenation

    Nicotine acetylcholine receptors can form countless heteromeric stoichiometries from a common set of subunits. Ahring et al. present the limitations of subunit concatenation and establish a refinement that achieves substantiated expression of uniform receptor pools from complex stoichiometric origins.

    Philip Kiær Ahring ... Thomas Balle
    Research Article | January 30, 2018
  • Molecular and functional identification of a novel photopigment in <em>Pecten</em> ciliary photoreceptors
    Go-coupled rhodopsin

    The mollusk Pecten irradians possesses ciliary photoreceptors that operate with an atypical mechanism. Arenas et al. reveal that a recently uncovered opsin type is the functional visual pigment in these photoreceptors and couples to Go, in contrast to other types of photoreceptor.

    Oscar Arenas ... Enrico Nasi
    Research Article | January 26, 2018

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The Journal of General Physiology: 150 (4)

Current Issue

April 2, 2018
Volume 150, No. 4

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Online ISSN: 1540-7748
Print ISSN: 0022-1295

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