Newest Articles
Ion-selective microelectrodes in voltage-clamped muscleMany cellular processes depend on the movement of ions across membranes, but current electrophysiological methods can only measure movements that generate an electrical current. Heiny et al. describe a new method to measure dynamic changes of intracellular ion concentration resulting from either electroneutral or electrogenic ion fluxes under voltage or current clamp.
David C. Gadsby, PhD: 1947–2019Andersen et al. commemorate the life of the eminent physiologist, David Gadsby.
The transport cycle of GlyT1 and GlyT2Erdem et al. compare the kinetics of the SLC6 family glycine transporters GlyT1 and GlyT2. Though the two transporters are rate-limited by distinct reaction steps, they both display high transport capacity, with the kinetics of GlyT1 sufficient to supply extracellular glycine to the NMDA receptor.
Light and EM studies of the plasma membraneTaraska reviews the imaging methods that are being used to understand the structure of the plasma membrane at the molecular level.
With PIPs, you get ZIPs and blipsSenning discusses new research on the regulation of two-pore sodium channels by different phosphoinositide phosphates.
Myosin orientation in muscleHigh-resolution structural information is invaluable for understanding muscle function. Savich et al. use bifunctional spin labeling to determine the orientation of the myosin lever arm in muscle fibers at high resolution under ambient conditions, augmenting previous insights obtained from fluorescence and EM.
PI3K regulation of heart rate and IFHeart rate is set by the specialized tissue of the sinoatrial node. Lin et al. demonstrate a novel role for phosphoinositide 3-kinase in regulating cardiac pacemaking currents independently of the autonomic nervous system, a finding with relevance for diabetes, heart disease, and cancer.
Phosphoinositide dependence of TPC3Among the three two-pore channels (TPCs), TPC1 and TPC2 are selectively activated by PI(3,5)P2, while TPC3 has been considered not to respond to any PIP2s. Shimomura and Kubo find that TPC3 responds to both PI(3,5)P2 and PI(3,4)P2, but not to PI(4,5)P2.
The mechanism of photon-like dark noise in rod photoreceptorsPugh highlights recent work ruling out a role for ultraweak photon emission in spontaneous photon-like events in retinal rods.
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Current Issue
October 7, 2019
Volume 151, No. 10
