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Newest Articles

  • Epilepsy-associated mutations in the voltage sensor of KCNQ3 affect voltage dependence of channel opening
    Epilepsy-causing mutation in S4 of KCNQ3

    KCNQ2 and KCNQ3 are subunits of the M channel, which regulates neuronal excitability. Using voltage clamp fluorometry, Barro-Soria reveals that the R230C mutation in KCNQ3, which causes hyperexcitability, shifts the voltage dependence of the open/closed transition to negative potentials.

    Rene Barro-Soria
    Research Article | December 21, 2018
  • Toward an understanding of the regulation of myofibrillar function
    Myofilament meeting 2018

    The first of two special issues dedicated to contractile systems highlights an emerging consensus that regulatory mechanisms involve thick and thin filaments.

    Richard L. Moss ... R. John Solaro
    Editorial | December 21, 2018
  • Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C
    Cardiac recovery with reexpression of cMyBP-C

    Knockdown of cardiac myosin binding protein C (cMyBP-C), which is the cause of many cases of hypertrophic cardiomyopathy in humans, results in left ventricular dilation, cardiac hypertrophy, and impaired ventricular function, but it is unclear whether these effects can be reversed. Using the Tet-Off system, Giles et al. show that these phenotypes can be induced and reversed with reexpression of cMyBP-C on the null background.

    Jasmine Giles ... Richard L. Moss
    Research Article | December 20, 2018
  • Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance
    Metformin ameliorates diastolic dysfunction

    Heart failure with preserved ejection fraction (HFpEF) is a syndrome characterized by increased diastolic stiffness, for which effective therapies are lacking. Slater et al. show that metformin lowers titin-based passive stiffness in an HFpEF mouse model and may therefore be of therapeutic benefit.

    Rebecca E. Slater ... Henk L. Granzier
    Research Article | December 19, 2018
  • Unlocking the gating mechanism of Kv2.1 using guangxitoxin
    Hanging on by the helix

    Navarro et al discuss new work using the gating-modifier toxin GxTx to investigate the molecular mechanism of Kv2.1 channel gating.

    Marco A. Navarro ... Mirela Milescu
    Commentary | December 18, 2018
  • cAMP binds to closed, inactivated, and open sea urchin HCN channels in a state-dependent manner
    State-dependent binding of cAMP to spHCN channels

    Mammalian hyperpolarization-activated cyclic-nucleotide–modulated (HCN) channels bind cAMP preferably in the open state. Using sea urchin HCN channels, Idikuda et al. reveal less cAMP binding to the closed state and further reduced binding to the inactivated state and thus demonstrate intricate communication between the gate and ligand-binding domain.

    Vinay Idikuda ... Lei Zhou
    Research Article | December 12, 2018
  • Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response
    RyR2 modulation by phosphorylation at S2030

    Phosphorylation is thought to play a role in modulation of the ryanodine receptor 2 channel. Using a S2030A knock-in mouse model, Potenza et al. reveal that phosphorylation of RyR2-S2030 mediates channel regulation during the β-adrenergic response.

    Duilio M. Potenza ... Ernst Niggli
    Research Article | December 12, 2018
  • Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation
    Destabilization of relaxation in hERG channels

    The human ether-à-go-go–related gene (hERG) encodes a delayed rectifier K+ channel with slow deactivation gating. Shi et al. find that acidic residues on S3 contribute to slow deactivation kinetics by stabilizing the relaxed state of the voltage sensor, which can be mitigated by extracellular protons.

    Yu Patrick Shi ... Tom W. Claydon
    Research Article | December 07, 2018
  • The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening
    Control of Cx26 gating by cytosolic domains

    The N14K mutation in the N-terminal domain of connexin26 produces gain-of-function hemichannels. Valdez Capuccino et al. reveal that the mutation disrupts intersubunit interactions between the N terminus and the second transmembrane domain–cytoplasmic loop transition.

    Juan M. Valdez Capuccino ... Jorge E. Contreras
    Research Article | December 07, 2018
  • Sarcomere length–dependent effects on Ca<sup>2+</sup>-troponin regulation in myocardium expressing compliant titin
    Titin compliance reduces length-dependent troponin regulation

    Increases in sarcomere length cause enhanced force generation in cardiomyocytes by an unknown mechanism. Li et al. reveal that titin-based passive tension contributes to length-dependent activation of myofilaments and that tightly bound myosin–actin cross-bridges are associated with this effect.

    King-Lun Li ... Wen-Ji Dong
    Research Article | December 06, 2018

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The Journal of General Physiology: 151 (2)

Current Issue

February 4, 2019
Volume 151, No. 2

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Online ISSN: 1540-7748
Print ISSN: 0022-1295

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