Newest Articles
Structure and function of NMDA receptorsHansen et al. review recent structural data that have provided insight into the function and allosteric modulation of NMDA receptors.
Mechanistic complexity of contractile dysfunction in hypertrophic cardiomyopathyReflections on recent work providing mechanistic insight into the pathological effects of a cardiac troponin T mutation.
Carriers, exchangers, and cotransporters in JGPJennings reviews the many contributions of JGP articles to our current understanding of solute transporter mechanisms.
Influences: Sodium channel excitementMandel reflects on the influence that a very broad training had on her scientific career.
Residue-specific propofol binding to NaChBacGeneral anesthetics inhibit voltage-gated sodium channels by unknown molecular mechanisms. Using computation-guided NMR and electrophysiology analyses, Wang et al. show that propofol binds to the prokaryotic sodium channel NaChBac at multiple distinct sites.
Mechanisms of propofol modulation in prokaryotic NavsDespite extensive use in clinical practice, the mechanisms of propofol action on sodium channels are not fully understood. Yang et al. incorporate complementary biophysical approaches (electrophysiology and molecular dynamics simulations) to demonstrate that propofol inhibits two prokaryotic voltage-gated sodium channels, NaChBac and NavMs, by modulating both activation and inactivation gating.
TMEM16A mediates fast block in Xenopus laevis eggsIn their preceding paper, Wozniak et al. show that fertilization increases intracellular Ca2+ in Xenopus laevis eggs by activating an IP3 signaling cascade. Here, they reveal that Ca2+ subsequently opens the Cl− channel TMEM16A to allow Cl− efflux, cell depolarization, and fast block to polyspermy.
IP3 induces fast polyspermy block in Xenopus eggsThe fast block to polyspermy is achieved in Xenopus laevis eggs by fertilization-induced depolarization. Wozniak et al. show that fertilization activates a signaling cascade involving phospholipase C, IP3, and intracellular Ca2+ release, which induces depolarization via Ca2+-activated Cl− efflux.
Biaryl sulfonamides activate ion channelsThere exist many different ion channel modulators that inhibit channel function, but few that increase it. Liin et al. tested 18,000 compounds by high-throughput electrophysiology and found several channel openers with a biaryl-sulfonamide motif that acts on the voltage-sensing machinery.
Bridging the gap toward understanding short-term synaptic plasticityJGP study explores a new way to conceptualize an enduring neuronal mystery.
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Current Issue
October 1, 2018
Volume 150, No. 10
